出生年月

1982.08

工      号

科　　别

护理学院

职　　称

中级

最高学历

博士

职      务

讲师

最高学位

博士研究生

毕业院校

中山大学

导师（打√）

硕 √  博 口

学      科

护理学

应诊时间：

出诊科室

联系电话：

15626209898

电子邮箱：

yanfengxia0807@163.com

个人简介（包括主要的学习工作经历、医疗专长、教学情况等）

2016年6月中山大学药学院博士毕业，毕业后继续在中山大学第一附属医院从事博士后相关研究工作，博士和博士后期间主要研究心脑血管相关疾病的病因和发病机制，并探讨该类疾病新的治疗靶点。现已发表SCI论文15篇，总计影响因子61.8分。博士后出站后于2017年11月到暨南大学护理学院从事教学和科研的相关工作，目前主要担任《社区护理》、《临床药理》和《外科护理学》课程的主讲工作。

社会任职

现任广东省护理学会护理信息专业委员会主委

研究方向（临床、课题）

临床护理、护理药理和慢性病的延续护理

荣誉与奖励

无

学术论著（近年发表的主要论文，专著请写明专著书名）

(1) Rifang Liao^#*, Fengxia Yan^#, Zhuanping Zeng^#, Haitao Wang, Kaifeng Qiu, Jinying Xua，Wenhua Zheng^*, Insulin-like growth factor-1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone-induced oxidative injury, Br J Pharmacol, 2018 Jan;175(1):125-139. (并列第一作者，IF=6.58)

(2) Yizhou Jiang^#, Fengxia Yan^#, Zhongping Feng, Philip Lazarovici, Wenhua Zheng^*,Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction，Cells, 2019 Dec 31;9(1). DOI: 10.3390/cells9010100, [Epub ahead of print]( 并列第一作者, IF=5.66)

(3) Fengxia Yan^#, HuaMing Li^#, ShangXuan Li^#, ShiHui He, WeiPing Dai, Yan Li, Tian Tian Wang, MaoMao Shi, HaoXiang Yuan, Zhe Xu, JiaGuo Zhou, DaSheng Ning, ZhiWei Mo, ZhiJun Ou^*, JingSong Ou^*, The oxidized phospholipid POVPC impairs endothelial function and vasodilation via uncoupling endothelial nitric oxide synthase, J Mol Cell Cardiol, 2017 Nov;112:40-48. （第一作者，IF=5.3）

(4) Rifang Liao^#, Fengxia Yan^#, Zhuanping Zeng^#, Mohd Farhan, Peter Little, Remi Quirion, Lalit K. Srivastava, Wenhua Zheng^*, Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway, Mol Neurobiol, (2017) 54:6931–6943. (并列第一作者，IF=4.58).

(5) Fengxia Yan^#, Rifang Liao^#, Marta Silva^#, Shuai Li^#, Yizhou Jiang, Tangming Peng, Philip Lazarovici,  Wenhua^*,ZhengPristimerin-induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway. J Cell Mol Med. 2020 Apr 29. doi: 10.1111/jcmm.15249. [Epub ahead of print]( (第一作者，IF=4.66).

(6) Fengxia Yan^#, HaiTao Wang^#, Yang Gao, Jiang Ping Xu, and Wenhua Zheng^*, Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage, ACS Chem Neurosci, 2017 Aug 16;8(8):1713-1723. (第一作者，IF=3.86)

(7) Xiaoying  Zhang^#，Lifang Wang ^#, Lizhi Peng^#，Xiaoying Tian, Xiaoyuan Qiu, Huan Cao, Qiaohong Yang^*,Rifang Liao^* and Fengxia Yan^*，Dihydromyricetin protects HUVECs of oxidative damage induced by sodium nitroprusside through activating PI3K/Akt/FoxO3a signalling pathway，J Cell Mol Med. 2019 May 21； doi: 10.1111/jcmm.14406，[Epub ahead of print].（通讯作者，IF=4.66）

(8) Fengxia Yan^#, Zilong Gao, Pin Chen, Li Huang, Dangui Wang, Na Chen, Ruixiang Wu, Jing Feng, Shan Cui, Wei Lu, JinHui Wang^*, Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory. Neural Plast, 2016 Dec 14. doi: 10.1155/2016/5648390，[Epub ahead of print]. （第一作者，IF=3.59）

(9) Fengxia Yan ^#, Rifang Liao^#, Mohd Farhan, Tinghuai Wang, Jiashu Chen, Zhong Wang, Peter J. Little, Wenhua Zheng^*, Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells, Biomedicine & Pharmacotherapy, 2016, 84(12): 1538–1550. (第一作者，IF=3.74)

(10) Rikang Wang^#, Fengxia Yan ^#, Rifang Liao^#, Pei Wan, Peter J.Little , Wenhua Zheng^*, Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo, Mol Cell Endocrinol, 2017 May 15;447:71-78. （并列第一作者，IF=3.69）

(11) Fengxia Yan^#, Rifang Liao^#, Peter J. Little, Wenhua Zheng^*, Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl2like protein 11 and cyclindependent kinase inhibitor 1B, Molecula Medicine Reports. 2018 Feb;17. doi: 10.3892/mmr.2017.8215, [Epub ahead of print].（第一作者，IF=1.85)

(12) Wenhua Zheng^*, Qian Meng, Haitao Wang, Fengxia Yan, Peter J. Little, Xinguo Deng, Shaofen Lin, IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway, Mol Neurobiol (2018) 55:1915–1927.(第四作者，IF=4.58)

(13) Shuai Li^#，Shubhash Chandra chaudhary^#, Xia Zhao^#, Uma Gaur，Jiankang Fang, Fengxia Yan and Wenhua Zheng^*，Artemisinin Protects Human Retinal Pigmented Epithelial Cells Against Hydrogen Peroxide-induced Oxidative Damage by Enhancing the Activation of AMP-active Protein Kinase, International Journal of Biological Sciences, 2019;15:2016-2028.(第六作者，IF=4.06)

(14) Haitao Wang^#, Sufei Liao^#, Ruojun Geng, Yongxin Zheng, Rifang Liao, Fengxia Yan, Thilini Thrimawithana, Peter J. Little, Zhongping Feng, Philip Lazarovici, Wenhua Zheng^*, IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprusside insult, Journal of Molecular Neuroscience, 2015, 55(4):931-40. (第六作者，IF=2.57)

(15) Liu Linlin^#, Zhiwen Zeng, Uma Gaur, Fengxia Yan and Wenhua Zheng^*，The p38-MAPK Pathway Is Involved in Neuroprotection of Artemisinin against H2O2-induced Apoptosis in PC12 Cells，Journal of Pharmacy and Pharmacology，7 (2017) 416-423（第四作者，IF=2.39).

科研项目

(1) FoxO3a对eNOS表达的调控在趋炎HDL介导血管舒张功能受损中的作用及机制研究，广州市基础与应用基础研究项目，主持，20万

(2) FoxO1转录因子对神经肽W表达的调控在抑郁症形成中的作用及机制研究，广东省自然科学基金面上项目，主持10万

(3) 青蒿素对H2O2诱导视网膜色素上皮细胞凋亡的保护作用及机制研究，暨南大学护理学院培育项目，主持，3万

(4) 青蒿素对氧化损伤视网膜色素上皮细胞的保护作用及机制的研究，广东省中药局项目，主持，1万

Fox03a 转录因子在葡萄膜黑色素痛中的作用及调节机制研究，广东省医学科研基金立项课题，主持，0.5万